This paper develops novel results in the harmonic analysis of Bessel operators, extending their theory to higher-dimensional and non-Euclidean spaces.We present a refined MISWAK TOOTHPASTE framework for Hardy spaces associated with Bessel operators, emphasizing atomic decompositions, dual spaces, and connections to Sobolev and Besov spaces.The spectral theory of families of boundary-interpolating operators is also expanded, offering precise eigenvalue estimates and functional calculus applications.Furthermore, we explore Bessel operators under non-standard measures, such as fractal and weighted geometries, uncovering Magnet new analytical phenomena.Key implications include advanced insights into singular integrals, heat kernel behavior, and the boundedness of Riesz transforms, with potential applications in fractal geometry, constrained wave propagation, and mathematical physics.